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Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy

Alrubayyi, Aljawharah; Rowland-Jones, Sarah; Peppa, Dimitra; (2022) Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy. AIDS , 36 (14) pp. 1903-1915. 10.1097/QAD.0000000000003319. Green open access

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Abstract

Despite progress in preexposure prophylaxis, the number of newly diagnosed cases with HIV-1 remains high, highlighting the urgent need for preventive and therapeutic strategies to reduce HIV-1 acquisition and limit disease progression. Early immunological events, occurring during acute infection, are key determinants of the outcome and course of disease. Understanding early immune responses occurring before viral set-point is established, is critical to identify potential targets for prophylactic and therapeutic approaches. Natural killer (NK) cells represent a key cellular component of innate immunity and contribute to the early host defence against HIV-1 infection, modulating the pathogenesis of acute HIV-1 infection (AHI). Emerging studies have identified tools for harnessing NK cell responses and expanding specialized NK subpopulations with adaptive/memory features, paving the way for development of novel HIV-1 therapeutics. This review highlights the knowns and unknowns regarding the role of NK cell subsets in the containment of acute HIV-1 infection, and summarizes recent advances in selectively augmenting NK cell functions through prophylactic and therapeutic interventions.

Type: Article
Title: Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/QAD.0000000000003319
Publisher version: https://doi.org/10.1097/QAD.0000000000003319
Language: English
Additional information: © 2022 Wolters Kluwer Health, Inc. This is an-open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0).
Keywords: Human immunodeficiency virus (HIV-1), Acute HIV-1 infection (AHI), Natural Killer (NK) cells, Cytomegalovirus (CMV), therapeutic treatment, antiretroviral therapy (ART)
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10153974
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