Alrubayyi, Aljawharah;
Rowland-Jones, Sarah;
Peppa, Dimitra;
(2022)
Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy.
AIDS
, 36
(14)
pp. 1903-1915.
10.1097/QAD.0000000000003319.
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Abstract
Despite progress in preexposure prophylaxis, the number of newly diagnosed cases with HIV-1 remains high, highlighting the urgent need for preventive and therapeutic strategies to reduce HIV-1 acquisition and limit disease progression. Early immunological events, occurring during acute infection, are key determinants of the outcome and course of disease. Understanding early immune responses occurring before viral set-point is established, is critical to identify potential targets for prophylactic and therapeutic approaches. Natural killer (NK) cells represent a key cellular component of innate immunity and contribute to the early host defence against HIV-1 infection, modulating the pathogenesis of acute HIV-1 infection (AHI). Emerging studies have identified tools for harnessing NK cell responses and expanding specialized NK subpopulations with adaptive/memory features, paving the way for development of novel HIV-1 therapeutics. This review highlights the knowns and unknowns regarding the role of NK cell subsets in the containment of acute HIV-1 infection, and summarizes recent advances in selectively augmenting NK cell functions through prophylactic and therapeutic interventions.
| Type: | Article |
|---|---|
| Title: | Natural killer cells during acute HIV-1 infection: clues for HIV-1 prevention and therapy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/QAD.0000000000003319 |
| Publisher version: | https://doi.org/10.1097/QAD.0000000000003319 |
| Language: | English |
| Additional information: | © 2022 Wolters Kluwer Health, Inc. This is an-open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0). |
| Keywords: | Human immunodeficiency virus (HIV-1), Acute HIV-1 infection (AHI), Natural Killer (NK) cells, Cytomegalovirus (CMV), therapeutic treatment, antiretroviral therapy (ART) |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10153974 |
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