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TiO2 Nanotopography-Driven Osteoblast Adhesion through Coulomb's Force Evolution

Luo, J; Zhao, S; Gao, X; Varma, SN; Xu, W; Tamaddon, M; Thorogate, R; ... Liu, C; + view all (2022) TiO2 Nanotopography-Driven Osteoblast Adhesion through Coulomb's Force Evolution. ACS applied materials & interfaces , 14 (30) pp. 34400-34414. 10.1021/acsami.2c07652. Green open access

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Abstract

Nanotopography is an effective method to regulate cells' behaviors to improve Ti orthopaedic implants' in vivo performance. However, the mechanism underlying cellular matrix-nanotopography interactions that allows the modulation of cell adhesion has remained elusive. In this study, we have developed novel nanotopographic features on Ti substrates and studied human osteoblast (HOb) adhesion on nanotopographies to reveal the interactive mechanism regulating cell adhesion and spreading. Through nanoflat, nanoconvex, and nanoconcave TiO2 nanotopographies, the evolution of Coulomb's force between the extracellular matrix and nanotopographies has been estimated and comparatively analyzed, along with the assessment of cellular responses of HOb. We show that HObs exhibited greater adhesion and spreading on nanoconvex surfaces where they formed super matured focal adhesions and an ordered actin cytoskeleton. It also demonstrated that Coulomb's force on nanoconvex features exhibits a more intense and concentrated evolution than that of nanoconcave features, which may result in a high dense distribution of fibronectin. Thus, this work is meaningful for novel Ti-based orthopaedic implants' surface designs for enhancing their in vivo performance.

Type: Article
Title: TiO2 Nanotopography-Driven Osteoblast Adhesion through Coulomb's Force Evolution
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.2c07652
Publisher version: https://doi.org/10.1021/acsami.2c07652
Language: English
Additional information: Copyright © 2022 The Authors. Published by American Chemical Society. This is an open access article under the CC BY 4.0 license Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)
Keywords: Ti implant, cell adhesion, cell−material interaction, nanotopography, protein adsorption, Cell Adhesion, Focal Adhesions, Humans, Osteoblasts, Surface Properties, Titanium
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10153828
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