Sanchez-Pastor Gomis, Alberto;
(2022)
A radiotherapy compatible QA phantom for HIFU.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
In order to produce a phantom that would be suited for combined radiotherapy and HIFU quality assurance, a gellan gum-based tissue mimicking material (TMM) has been developed. Gellan gum is a material that has been used for the creation of acoustic phantoms but has not been applied to any radiotherapy work. The TMM’s acoustic properties have been characterized. Geared toward enabling it to perform metrology of acoustic sources, a thermochromic variant has been developed. The thermochromic and non-thermochromic variants of the TMM have been compared in terms of their acoustic properties to ensure that the materials could be combined for the creation of phantoms. To test the TMM’s applicability to radiotherapy applications the samples have been characterized pre- and post-irradiation (up to 3kGy) to ensure the applicability of the phantom to uses that require the material be exposed to ionizing radiation. The TMM has also been characterized in terms of its Hounsfield Units to assess its possible use as a phantom for radiation applications, and a comparison of measured and simulated attenuation has been used to verify that the effective atomic number is similar to that of human tissues. The TMMs have been combined for the development of a Quality Assurance (QA) phantom for an ultrasound guided HIFU therapy. A QA process has been developed, with associated software, which allows a simple QA process that can identify changes in power output and assess the targeting capabilities of an US-guided thermal therapy inexpensively. The thermochromic TMM has also been applied to the detection of the focal position in a mouse skull phantom. The materials have been shown to be applicable to both combined, and separate, radiotherapy and HIFU applications, as well as to ultrasound guided therapies.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | A radiotherapy compatible QA phantom for HIFU |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10153689 |
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