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Neural crest mechanosensors: Seeing old proteins in a new light

Canales Coutiño, Brenda; Mayor, Roberto; (2022) Neural crest mechanosensors: Seeing old proteins in a new light. Developmental Cell , 57 (15) pp. 1792-1801. 10.1016/j.devcel.2022.07.005. Green open access

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Abstract

Mechanical forces exerted on neural crest cells control their collective migration and differentiation. This perspective discusses our current understanding of neural crest mechanotransduction during cell migration and differentiation. Additionally, we describe proteins that have mechanosensitive functions in other systems, such as mechanosensitive G-protein-coupled receptors, mechanosensitive ion channels, cell-cell adhesion, and cell-matrix-interacting proteins, and highlight that these same proteins have in the past been studied in neural crest development from a purely signaling point of view. We propose that future studies elucidate the mechanosensitive functions these receptors may play in neural crest development and integrate this with their known molecular role.

Type: Article
Title: Neural crest mechanosensors: Seeing old proteins in a new light
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2022.07.005
Publisher version: https://doi.org/10.1016/j.devcel.2022.07.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: GPCR, ion channels, mechanics, mechanotransduction, neural crest
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10153688
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