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Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported

Petzold, Axel; Plant, Gordon T; (2014) Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported. Journal of Neurology , 261 (1) pp. 17-26. 10.1007/s00415-013-6957-4. Green open access

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Abstract

Chronic relapsing inflammatory optic neuropathy (CRION) is an entity that was described in 2003. Early recognition of patients suffering from CRION is relevant because of the associated risk for blindness if treated inappropriately. It seems timely to have a clinical review on this recently defined entity. A systematic literature review, irrespective of language, retrieved 22 case series and single reports describing 122 patients with CRION between 2003 and 2013. We review the epidemiology, diagnostic workup, differential diagnosis, and treatment (acute, intermediate, and long term) in view of the collective data. These data suggest that CRION is a distinct nosological entity, which is seronegative for anti-aquaporin four auto-antibodies and recognized by and managed through its dependency on immuno-suppression. Revised diagnostic criteria are proposed in light of the data compromising a critical discussion of relevant limitations. © 2013 Springer-Verlag Berlin Heidelberg.

Type: Article
Title: Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00415-013-6957-4
Publisher version: https://doi.org/10.1007/s00415-013-6957-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Optic neuritis, Steroid-dependent optic neuritis, Relapse, ON, CRION
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10153214
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