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Stem cells, cell therapies, and bioengineering in lung biology and disease 2021

Ikonomou, Laertis; Magnusson, Mattias; Dries, Ruben; Herzog, Erica L; Hynds, Robert; Borok, Zea; Park, Jin-Ah; ... Ryan, Amy L; + view all (2022) Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. American Journal of Physiology: Lung Cellular and Molecular Physiology , 323 (3) L342-L354. 10.1152/ajplung.00113.2022. Green open access

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Abstract

The 9th biennial conference titled "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases" was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held July 9th. As in previous years the objectives remained to review and discuss the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung. Topics included: 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signalling and plasticity in lung remodelling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology. The virtual workshop included active discussion on state-of-the-art methods relating to the core features of the 2021 conference, including in-situ protemics, lung-on-chip, iPSC-airway differentiation, and light sheet microscopy. The conference concluded with an open discussion to suggest funding priorities and recommendations for future research directions in basic and translational lung biology.

Type: Article
Title: Stem cells, cell therapies, and bioengineering in lung biology and disease 2021
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/ajplung.00113.2022
Publisher version: https://doi.org/10.1152/ajplung.00113.2022
Language: English
Additional information: Copyright © 2022 The Authors. Licensed under Creative Commons Attribution CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/deed.en_US). Published by the American Physiological Society.
Keywords: Bioengineering, extracellular matrix, lung regeneration, pluripotent stem cells, proteomics
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10153135
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