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Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia

Guellil, Meriam; van Dorp, Lucy; Inskip, Sarah A; Dittmar, Jenna M; Saag, Lehti; Tambets, Kristiina; Hui, Ruoyun; ... Scheib, Christiana L; + view all (2022) Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia. Science Advances , 8 (30) , Article eabo4435. 10.1126/sciadv.abo4435. Green open access

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Abstract

Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a majority of adults globally. Phylogeographic clustering of sampled diversity into European, pan-Eurasian, and African groups has suggested the virus codiverged with human migrations out of Africa, although a much younger origin has also been proposed. We present three full ancient European HSV-1 genomes and one partial genome, dating from the 3rd to 17th century CE, sequenced to up to 9.5× with paired human genomes up to 10.16×. Considering a dataset of modern and ancient genomes, we apply phylogenetic methods to estimate the age of sampled modern Eurasian HSV-1 diversity to 4.68 (3.87 to 5.65) ka. Extrapolation of estimated rates to a global dataset points to the age of extant sampled HSV-1 as 5.29 (4.60 to 6.12) ka, suggesting HSV-1 lineage replacement coinciding with the late Neolithic period and following Bronze Age migrations.

Type: Article
Title: Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.abo4435
Publisher version: https://doi.org/10.1126/sciadv.abo4435
Language: English
Additional information: Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10153076
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