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Factors affecting antimicrobial resistance in Streptococcus pneumoniae following vaccination introduction

Watkins, Eleanor Rose; Kalizang'Oma, Akuzike; Gori, Andrea; Gupta, Sunetra; Heyderman, Robert S; (2022) Factors affecting antimicrobial resistance in Streptococcus pneumoniae following vaccination introduction. Trends in Microbiology 10.1016/j.tim.2022.06.001. (In press).

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Abstract

Streptococcus pneumoniae is a major cause of pneumonia, meningitis, and septicaemia worldwide. Pneumococcal antimicrobial resistance (AMR) has been highlighted by the WHO as an important public health concern, with emerging serotypes showing resistance to multiple antibiotics. Indeed, although the introduction of pneumococcal conjugate vaccines (PCVs) has been associated with an overall decline in pneumococcal AMR, there have been increases in prevalence of potentially disease-causing AMR serotypes not targeted by vaccination. Here, we discuss a variety of evolutionary mechanisms at the host, pathogen, and environmental levels that may contribute to changes in the prevalence of pneumococcal AMR in the post-vaccination era. The relative importance of these factors may vary by population, pneumococcal lineage, geography, and time, leading to the complex relationship between vaccination, antibiotic use, and AMR.

Type: Article
Title: Factors affecting antimicrobial resistance in Streptococcus pneumoniae following vaccination introduction
Location: England
DOI: 10.1016/j.tim.2022.06.001
Publisher version: https://doi.org/10.1016/j.tim.2022.06.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Streptococcus pneumoniae, antimicrobial resistance, evolution, vaccination
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10152920
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