Samaras, JJ;
Micheletti, M;
Ding, W;
(2022)
Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development.
Annual Review of Chemical and Biomolecular Engineering
, 13
(1)
pp. 73-97.
10.1146/annurev-chembioeng-092220-030223.
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Abstract
Single-use technologies have transformed conventional biopharmaceutical manufacturing, and their adoption is increasing rapidly for emerging applications like antibody-drug conjugates and cell and gene therapy products. These disruptive technologies have also had a significant impact during the coronavirus disease 2019 pandemic, helping to advance process development to enable the manufacturing of new monoclonal antibody therapies and vaccines. Single-use systems provide closed plug-and-play solutions and enable process intensification and continuous processing. Several challenges remain, providing opportunities to advance single-use sensors and their integration with single-use systems, to develop novel plastic materials, and to standardize design for interchangeability. Because the industry is changing rapidly, a holistic analysis of the current single-use technologies is required, with a summary of the latest advancements in materials science and the implementation of these technologies in end-to-end bioprocesses.
| Type: | Article |
|---|---|
| Title: | Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development |
| Location: | United States |
| DOI: | 10.1146/annurev-chembioeng-092220-030223 |
| Publisher version: | https://doi.org/10.1146/annurev-chembioeng-092220-... |
| Language: | English |
| Additional information: | The published version can be viewed via the Annual Reviews–supplied ePrint URL: http://www.annualreviews.org/eprint/6A3QP7RCSV22WNTS6AWP/full/10.1146/annurev-chembioeng-092220-030223 - Please refer to the publisher’s terms and conditions for further information. |
| Keywords: | Science & Technology, Physical Sciences, Technology, Chemistry, Applied, Engineering, Chemical, Chemistry, Engineering, single-use technology, single-use systems, materials science, bioreactors, perfusion, continuous biomanufacturing, LIFE-CYCLE ASSESSMENT, PRE-PACKED COLUMNS, DISPOSABLE TECHNOLOGIES, GAMMA-IRRADIATION, MULTILAYER FILMS, USE SYSTEMS, CELLS, POLYETHYLENE, SENSORS, IMPACT |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10152781 |
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