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Vaccinations in Children and Adolescents Treated With Immune-Modifying Biologics: Update and Current Developments

Martire, Baldassarre; Ottaviano, Giorgio; Sangerardi, Maria; Sgrulletti, Mayla; Chini, Loredana; Dellepiane, Rosa Maria; Montin, Davide; ... Moschese, Viviana; + view all (2022) Vaccinations in Children and Adolescents Treated With Immune-Modifying Biologics: Update and Current Developments. The Journal of Allergy and Clinical Immunology: In Practice , 10 (6) pp. 1485-1496. 10.1016/j.jaip.2022.01.007. Green open access

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Abstract

Treatment with immune modifying biologicals has positively impacted disease control and quality of life in many patients with immune-mediated disorders. However, the higher susceptibility to common and opportunistic pathogens is of concern. Thus, immunization strategies to control vaccine preventable diseases represent a critical issue in this population. However, limited data exist on the safety, immunogenicity and efficacy of available vaccines in patients on biologicals, particularly in children. Here, according to published literature and real life experience and practice, we report the interim indications of the Italian Society of Pediatric Allergology and Immunology (SIAIP) Vaccine Committee and of the Italian Primary Immunodeficiency Network (IPINET) Centers, on immunization of children and adolescents receiving biologicals. Our aim is to provide a practical guidance for the clinician to ensure optimal protection for patients and the community.

Type: Article
Title: Vaccinations in Children and Adolescents Treated With Immune-Modifying Biologics: Update and Current Developments
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jaip.2022.01.007
Publisher version: https://doi.org/10.1016/j.jaip.2022.01.007
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biologics, Children, Vaccinations, Adolescent, Biological Products, Child, Humans, Immunization, Quality of Life, Vaccination, Vaccines
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10152137
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