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An efficient method to identify, date, and describe admixture events using haplotype information

Wangkumhang, Pongsakorn; Greenfield, Matthew; Hellenthal, Garrett; (2022) An efficient method to identify, date, and describe admixture events using haplotype information. Genome Research 10.1101/gr.275994.121. (In press). Green open access

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Abstract

We present fastGLOBETROTTER, an efficient new haplotype-based technique to identify, date, and describe admixture events using genome-wide autosomal data. With simulations, we demonstrate how fastGLOBETROTTER reduces computation time by an order of magnitude relative to the related technique GLOBETROTTER without suffering loss of accuracy. We apply fastGLOBETROTTER to a cohort of >6000 Europeans from ten countries, revealing previously unreported admixture signals. In particular we infer multiple periods of admixture related to East Asian or Siberian-like sources, starting >2000 years ago, in people living in countries north of the Baltic Sea. In contrast, we infer admixture related to West Asian, North African and/or Southern European sources in populations south of the Baltic Sea, including admixture dated to ≈300-700CE, overlapping the fall of the Roman Empire, in people from Belgium, France and parts of Germany. Our new approach scales to analyzing hundreds to thousands of individuals from a putatively admixed population and hence is applicable to emerging large-scale cohorts of genetically homogeneous populations.

Type: Article
Title: An efficient method to identify, date, and describe admixture events using haplotype information
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/gr.275994.121
Publisher version: https://doi.org/10.1101/gr.275994.121
Language: English
Additional information: This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International license), as described at http://creativecommons.org/licenses/by/4.0/.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10152060
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