Wangkumhang, Pongsakorn;
Greenfield, Matthew;
Hellenthal, Garrett;
(2022)
An efficient method to identify, date, and describe admixture events using haplotype information.
Genome Research
10.1101/gr.275994.121.
(In press).
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Abstract
We present fastGLOBETROTTER, an efficient new haplotype-based technique to identify, date, and describe admixture events using genome-wide autosomal data. With simulations, we demonstrate how fastGLOBETROTTER reduces computation time by an order of magnitude relative to the related technique GLOBETROTTER without suffering loss of accuracy. We apply fastGLOBETROTTER to a cohort of >6000 Europeans from ten countries, revealing previously unreported admixture signals. In particular we infer multiple periods of admixture related to East Asian or Siberian-like sources, starting >2000 years ago, in people living in countries north of the Baltic Sea. In contrast, we infer admixture related to West Asian, North African and/or Southern European sources in populations south of the Baltic Sea, including admixture dated to ≈300-700CE, overlapping the fall of the Roman Empire, in people from Belgium, France and parts of Germany. Our new approach scales to analyzing hundreds to thousands of individuals from a putatively admixed population and hence is applicable to emerging large-scale cohorts of genetically homogeneous populations.
Type: | Article |
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Title: | An efficient method to identify, date, and describe admixture events using haplotype information |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1101/gr.275994.121 |
Publisher version: | https://doi.org/10.1101/gr.275994.121 |
Language: | English |
Additional information: | This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International license), as described at http://creativecommons.org/licenses/by/4.0/. |
UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10152060 |
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