Graedel, Nadine N;
Miller, Karla L;
Chiew, Mark;
(2022)
Ultrahigh Resolution fMRI at 7T Using Radial-Cartesian TURBINE Sampling.
Magnetic Resonance in Medicine
10.1002/mrm.29359.
(In press).
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Abstract
PURPOSE: We investigate the use of TURBINE, a 3D radial-Cartesian acquisition scheme in which EPI planes are rotated about the phase-encoding axis to acquire a cylindrical k-space for high-fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring. METHODS: An improved, completely self-navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin-slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole-brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias. RESULTS: TURBINE images provide high structural fidelity with almost no distortion, dropout, or T2^{*} blurring for the thin-slab acquisitions compared to conventional 3D EPI owing to the radial sampling in-plane and the short echo train used. This results in activation that can be localized to pre- and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T_{1} -MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole-brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin-slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole-brain) acquisitions. CONCLUSION: TURBINE is a promising acquisition approach for high-resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B_{0} inhomogeneity.
| Type: | Article |
|---|---|
| Title: | Ultrahigh Resolution fMRI at 7T Using Radial-Cartesian TURBINE Sampling |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.29359 |
| Publisher version: | https://doi.org/10.1002/mrm.29359 |
| Language: | English |
| Additional information: | © 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | 7T, TURBINE, fMRI, high-resolution fMRI, radial-Cartesian, ultrahigh-field MRI |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10151968 |
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