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Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster

Anderson, Lucy; Camus, M Florencia; Monteith, Katy M; Salminen, Tiina S; Vale, Pedro F; (2022) Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster. Heredity 10.1038/s41437-022-00554-w. (In press). Green open access

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Abstract

Mitochondria are organelles that produce cellular energy in the form of ATP through oxidative phosphorylation, and this primary function is conserved among many taxa. Locomotion is a trait that is highly reliant on metabolic function and expected to be greatly affected by disruptions to mitochondrial performance. To this end, we aimed to examine how activity and sleep vary between Drosophila melanogaster strains with different geographic origins, how these patterns are affected by mitochondrial DNA (mtDNA) variation, and how breaking up co-evolved mito-nuclear gene combinations affect the studied activity traits. Our results demonstrate that Drosophila strains from different locations differ in sleep and activity, and that females are generally more active than males. By comparing activity and sleep of mtDNA variants introgressed onto a common nuclear background in cytoplasmic hybrid (cybrid) strains, we were able to quantify the among-line variance attributable to mitochondrial DNA, and we establish that mtDNA variation affects both activity and sleep, in a sex-specific manner. Altogether our study highlights the important role that mitochondrial genome variation plays on organismal physiology and behaviour.

Type: Article
Title: Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41437-022-00554-w
Publisher version: https://doi.org/10.1038/s41437-022-00554-w
Language: English
Additional information: © 2022 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Behavioural genetics, Drosophila, Genetic models
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10151907
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