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Rhazinilam-leuconolam family of natural products: a half century of total synthesis

Sirindil, Fatih; Weibel, Jean-Marc; Pale, Patrick; Blanc, Aurelien; (2022) Rhazinilam-leuconolam family of natural products: a half century of total synthesis. Natural Product Reports 10.1039/d2np00026a. (In press). Green open access

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Abstract

Covering: 1972 to 2021The rhazinilam family of natural products exhibits a main structure with a stereogenic quaternary carbon and a tetrahydroindolizine core imbedded within a 9-membered macrocycle, imposing axial chirality. This unique architecture combined with their taxol-like antimitotic activities have attracted various attention, especially from synthetic chemists, notably in the past decade. The present review describes the known total and formal syntheses of the members of the rhazinilam family (rhazinilam, rhazinal, leuconolam and kopsiyunnanines), according to the strategy developed.

Type: Article
Title: Rhazinilam-leuconolam family of natural products: a half century of total synthesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d2np00026a
Publisher version: https://doi.org/10.1039/D2NP00026A
Language: English
Additional information: © The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10151625
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