Salaris, Nikolaos;
(2022)
Advancing optoelectronic oxygen sensing with phosphorescent films through system configuration and morphology control.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
The research presented in this thesis focuses on the advancement of optoelectronic oxygen sensing with the vision of medical translation and commercialisation. The motivation stems from medical applications and the physical principles of operation rely on quenching of phosphorescence. The methodology followed is based on optoelectronic instrumentation and off-the-shelf components. The phosphorescent dye PtOEP is encapsulated in polymer matrices and inexpensive fabrication techniques are applied for morphology control. First, optimal windows of performance are identified through parametric variation of configuration and signal variables with the aim of maximizing output signal to noise ratio. Results showed the existence of favourable positioning of optical components and specific input signal characteristics, leading to an improvement of up to ∼ 3.3 in output dynamic range. By extension, readily available polymers in tandem with simple fabrication techniques are employed to enhance the sensitivity of oxygen indicators by inducing porosity. As a result, a ∼ 7 fold increase in sensitivity was achieved. Additionally, an oxygen sensing and surface morphology analysis showed that the desirable characteristics depend on the type of setup (reflection or transmission based) and that the Breath Figure technique is preferable. Finally, spray drying is used towards the creation of microfibers embedded with the oxygen sensitive dye with the purpose of cell culture monitoring and a simultaneous mammalian cell proliferation. Their potential use for wearable applications via coating with polymer rubbers was also proposed due to the improved mechanical properties, with an elongation of up to ∼ 10 demonstrated. In conclusion, it was shown that the effective use of widely available materials in conjunction with simple fabrication techniques lead to significant improvements in optoelectronic oxygen sensing and consequently aid in its future commercial adoption.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Advancing optoelectronic oxygen sensing with phosphorescent films through system configuration and morphology control |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150904 |
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