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The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis

Fantin, Alessandro; Ruhrberg, Christiana; (2022) The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis. Methods in Molecular Biology , 2475 pp. 275-287. 10.1007/978-1-0716-2217-9_20.

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Abstract

Angiogenesis, the growth of new blood vessels from pre-existing ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining and analysis.

Type: Article
Title: The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis
Location: United States
DOI: 10.1007/978-1-0716-2217-9_20
Publisher version: https://doi.org/10.1007/978-1-0716-2217-9_20
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Angiogenesis, Hindbrain, Retina
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10150807
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