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Investigation of 3D-printed chitosan-xanthan gum patches

Altan, Eray; Turker, Nurgul; Hindy, Osama Ali; Dirican, Zeynep; Ozakpinar, Ozlem Bingol; Demir, Aysegul Uzuner; Kalaskar, Deepak; ... Gunduz, Oguzhan; + view all (2022) Investigation of 3D-printed chitosan-xanthan gum patches. International Journal of Biological Macromolecules , 213 pp. 259-267. 10.1016/j.ijbiomac.2022.05.158.

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Abstract

In this study, using a new polymer combination of Chitosan(CH)/Xanthan Gum(XG) has been exhibited for wound dressing implementation by the 3D-Printing method, which was fabricated due to its biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of XG were added to the CH solution as 0.25, 0.50, 0.75, 1, and 2 wt% respectively in the formic acid/distilled water (1.5:8.5) solution and rheologically characterized to evaluate their printability. The results demonstrated that high mechanical strength, hydrophilic properties, and slow degradation rate were observed with the presence and increment of XG concentration within the 3D-Printed patches. Moreover, in vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on the patches, proving the cell proliferation rate, viability, and adhesion. Finally, 1% XG and 4% CH containing 3D-Printed patches were great potential for wound dressing applications.

Type: Article
Title: Investigation of 3D-printed chitosan-xanthan gum patches
Location: Netherlands
DOI: 10.1016/j.ijbiomac.2022.05.158
Publisher version: https://doi.org/10.1016/j.ijbiomac.2022.05.158
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 3D printing, Biomaterials, Optimisation, Wound dressing
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10150756
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