UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Anti-type I interferon antibodies as a cause of severe COVID-19

Fajgenbaum, David C; Hayday, Adrian C; Rogers, Angela J; Towers, Gregory J; Wack, Andreas; Zanoni, Ivan; (2022) Anti-type I interferon antibodies as a cause of severe COVID-19. Faculty Reviews , 11 , Article 15. 10.12703/r-01-0000010.

[thumbnail of article (2).pdf] Text
article (2).pdf - Published Version
Access restricted to UCL open access staff until 11 December 2022.

Download (1MB)

Abstract

COVID-19 ranges from asymptomatic through to respiratory failure and death. Although specific pre-existing conditions such as age and male sex have been associated with poor outcomes, we remain largely ignorant of the mechanisms predisposing to severe disease. In this study, the authors discovered that approximately 10% of 987 patients with life-threatening COVID-19 harbored neutralizing antibodies to Type I interferons (IFNs) [1]. They demonstrated that these antibodies could neutralize high concentrations of the corresponding IFN and could rescue SARS-CoV-2 infection from inhibition by IFN in vitro. Importantly, anti-IFN antibodies were associated with low levels of serum IFN. These observations suggest that disease severity in these individuals results from a failure to control SARS-CoV-2 replication because of antibody-mediated IFN inhibition. The study suggests specific treatments and diagnostics for this class of severe COVID-19.

Type: Article
Title: Anti-type I interferon antibodies as a cause of severe COVID-19
DOI: 10.12703/r-01-0000010
Publisher version: https://doi.org/10.12703/r-01-0000010
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10150675
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item