Reynolds, Catherine J;
Pade, Corinna;
Gibbons, Joseph M;
Otter, Ashley D;
Lin, Kai-Min;
Muñoz Sandoval, Diana;
Pieper, Franziska P;
... Moon, James C; + view all
(2022)
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure.
Science
10.1126/science.abq1841.
(In press).
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Abstract
The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
| Type: | Article |
|---|---|
| Title: | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1126/science.abq1841 |
| Publisher version: | https://doi.org/10.1126/science.abq1841 |
| Language: | English |
| Additional information: | © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). |
| Keywords: | COVIDsortium Investigators‡, COVIDsortium Immune Correlates Network‡ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150562 |
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