Castelletti, Silvia;
Menacho, Katia;
Davies, Rhodri H;
Maestrini, Viviana;
Treibel, Thomas A;
Rosmini, Stefania;
Manisty, Charlotte;
... Moon, James C; + view all
(2021)
Hypertrophic cardiomyopathy: insights from extracellular volume mapping.
European Journal of Preventive Cardiology
, 28
(18)
e39-e41.
10.1093/eurjpc/zwaa083.
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Abstract
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease characterized by myocardial hypertrophy and fibrosis. The phenotypic expression ranges from asymptomatic patients to heart failure and sudden death.1 Disease progression and relationship between hypertrophy and fibrosis are not well understood. Extracellular volume fraction (ECV) mapping on cardiovascular magnetic resonance (CMR) can demonstrate pixel-by-pixel ECV elevation (focal or diffuse fibrosis) or reduction (cellular hypertrophy).2 Furthermore, it has been shown that physical training induces remodelling of both heart and vasculature.3,4 In particular, it has been shown that hypertrophied myocardium in athletes has lower ECV, suggesting that cardiac athletic adaptation is an adaptive one caused predominantly by cellular rather than interstitial expansion.4 Hypothesizing that ECV mapping can reveal both differential responses of left ventricular hypertrophy (LVH), we explored the distribution of ECV in HCM.
| Type: | Article |
|---|---|
| Title: | Hypertrophic cardiomyopathy: insights from extracellular volume mapping |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/eurjpc/zwaa083 |
| Publisher version: | https://doi.org/10.1093/eurjpc/zwaa083 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150376 |
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