UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Hypertrophic cardiomyopathy: insights from extracellular volume mapping

Castelletti, Silvia; Menacho, Katia; Davies, Rhodri H; Maestrini, Viviana; Treibel, Thomas A; Rosmini, Stefania; Manisty, Charlotte; ... Moon, James C; + view all (2021) Hypertrophic cardiomyopathy: insights from extracellular volume mapping. European Journal of Preventive Cardiology , 28 (18) e39-e41. 10.1093/eurjpc/zwaa083. Green open access

[thumbnail of Manisty_Hypertrophic cardiomyopathy_AAM.pdf]
Preview
Text
Manisty_Hypertrophic cardiomyopathy_AAM.pdf

Download (204kB) | Preview

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease characterized by myocardial hypertrophy and fibrosis. The phenotypic expression ranges from asymptomatic patients to heart failure and sudden death.1 Disease progression and relationship between hypertrophy and fibrosis are not well understood. Extracellular volume fraction (ECV) mapping on cardiovascular magnetic resonance (CMR) can demonstrate pixel-by-pixel ECV elevation (focal or diffuse fibrosis) or reduction (cellular hypertrophy).2 Furthermore, it has been shown that physical training induces remodelling of both heart and vasculature.3,4 In particular, it has been shown that hypertrophied myocardium in athletes has lower ECV, suggesting that cardiac athletic adaptation is an adaptive one caused predominantly by cellular rather than interstitial expansion.4 Hypothesizing that ECV mapping can reveal both differential responses of left ventricular hypertrophy (LVH), we explored the distribution of ECV in HCM.

Type: Article
Title: Hypertrophic cardiomyopathy: insights from extracellular volume mapping
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/eurjpc/zwaa083
Publisher version: https://doi.org/10.1093/eurjpc/zwaa083
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10150376
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item