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Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid

Torres-Acosta, Mario A; Castaneda-Aponte, Hector M; Mora-Galvez, Liliana M; Gil-Garzon, Monica R; Banda-Magana, Martin P; Marcellin, Esteban; Mayolo-Deloisa, Karla; (2021) Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid. Frontiers in Bioengineering and Biotechnology , 9 , Article 680278. 10.3389/fbioe.2021.680278. Green open access

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Abstract

Hyaluronic acid (HA) is a biopolymer with a wide range of applications, mainly in the cosmetic and pharmaceutical sectors. Typical industrial-scale production utilizes organisms that generate HA during their developmental cycle, such as Streptococcus equi sub. zooepidemicus. However, a significant disadvantage of using Streptococcus equi sub. zooepidemicus is that it is a zoonotic pathogen, which use at industrial scale can create several risks. This creates opportunities for heterologous, or recombinant, production of HA. At an industrial scale, the recovery and purification of HA follow a series of precipitation and filtration steps. Current recombinant approaches are developing promising alternatives, although their industrial implementation has yet to be adequately assessed. The present study aims to create a theoretical framework to forecast the advantages and disadvantages of endogenous and recombinant strains in production with the same downstream strategy. The analyses included a selection of the best cost-related recombinant and endogenous production strategies, followed by a sensitivity analysis of different production variables in order to identify the three most critical parameters. Then, all variables were analyzed by varying them simultaneously and employing multiple linear regression. Results indicate that, regardless of HA source, production titer, recovery yield and bioreactor scale are the parameters that affect production costs the most. Current results indicate that recombinant production needs to improve current titer at least 2-fold in order to compete with costs of endogenous production. This study serves as a platform to inform decision-making for future developments and improvements in the recombinant production of HA.

Type: Article
Title: Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fbioe.2021.680278
Publisher version: https://doi.org/10.3389/fbioe.2021.680278
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Multidisciplinary Sciences, Science & Technology - Other Topics, hyaluronic acid, techno-economic analysis, recombinant production, endogenous production, cost of goods, PERFUSION CULTURE PROCESSES, AQUEOUS 2-PHASE EXTRACTION, DECISION-SUPPORT TOOL, FED-BATCH, PURIFICATION, STRATEGIES, PRECIPITATION, UNCERTAINTY, RECOVERY
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10150211
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