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A novel superfamily of bridge-like lipid transfer proteins

Neuman, Sarah D; Levine, Tim P; Bashirullah, Arash; (2022) A novel superfamily of bridge-like lipid transfer proteins. Trends in Cell Biology , 32 (11) pp. 962-974. 10.1016/j.tcb.2022.03.011.

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Abstract

Lipid transfer proteins mediate nonvesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Recently, a new type of bridge-like lipid transfer protein has emerged; these proteins contain a long hydrophobic groove and can mediate bulk transport of lipids between organelles. Here, we review recent insights into the structure of these proteins and identify a repeating modular unit that we propose to name the repeating β-groove (RBG) domain. This new structural understanding conceptually unifies all the RBG domain-containing lipid transfer proteins as members of an RBG protein superfamily. We also examine the biological functions of these lipid transporters in normal physiology and disease and speculate on the evolutionary origins of RBG proteins in bacteria.

Type: Article
Title: A novel superfamily of bridge-like lipid transfer proteins
Location: England
DOI: 10.1016/j.tcb.2022.03.011
Publisher version: https://doi.org/10.1016/j.tcb.2022.03.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: AlphaFold, Vps13, autophagy, lipid transfer proteins, lipids, membrane contact sites
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10150146
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