Barisa, Marta;
Fowler, Daniel;
Nattress, Callum;
Fisher, Jonathan;
(2022)
Preclinical platforms to study therapeutic efficacy of human γδT‐cells for oncology indications.
Clinical and Translational Discovery
, 2
(2)
, Article e72. 10.1002/ctd2.72.
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Abstract
In this commentary, we discuss recent advances in the study of γδT cell-based immunotherapeutics. As an allo-compatible cell therapy chassis without clear functional homologs in mice, γδT cells represent a challenge and an opportunity for preclinical modelling. We discuss some of the techniques and approaches that can be used to demonstrate and characterise γδT cell behaviour in biomimetic systems.
| Type: | Article |
|---|---|
| Title: | Preclinical platforms to study therapeutic efficacy of human γδT‐cells for oncology indications |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ctd2.72 |
| Publisher version: | https://doi.org/10.1002/ctd2.72 |
| Language: | English |
| Additional information: | © 2022 The Authors. Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150139 |
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