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The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis

Chiaravalloti, Nancy D; DeLuca, John; Salter, Amber; Amato, Maria Pia; Brichetto, Giampaolo; Chataway, Jeremy; Dalgas, Ulrik; ... Feinstein, Anthony; + view all (2022) The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis. Multiple Sclerosis Journal 10.1177/13524585221088190. (In press). Green open access

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Abstract

Objective: Processing speed (PS) deficits are the most common cognitive deficits in multiple sclerosis (MS), followed by learning and memory deficits, and are often an early cognitive problem. It has been argued that impaired PS is a primary consequence of MS, which in turn decreases learning. The current analysis examined the association between PS and learning in a large cohort of individuals with progressive MS. Methods: Baseline data from a randomized clinical trial on rehabilitation taking place at 11 centers across North America and Europe were analyzed. Participants included 275 individuals with clinically definite progressive MS (primary, secondary) consented into the trial. Results: Symbol Digit Modalities Test (SDMT) significantly correlated with California Verbal Learning Test-II (CVLT-II) (r = 0.21, p = 0.0003) and Brief Visuospatial Memory Test–Revised (BVMT-R) (r = 0.516, p < 0.0001). Receiver operating characteristic (ROC) analysis of the SDMT z score to distinguish between impaired and non-impaired CVLT-II performance demonstrated an area under the curve (AUC) of 0.61 (95% confidence interval (CI): 0.55–0.68) and a threshold of −1.62. ROC analysis between SDMT and BVMT-R resulted in an AUC of 0.77 (95% CI: 0.71–0.83) and threshold of −1.75 for the SDMT z score to predict impaired BVMT-R. Conclusion: Results indicate little ability beyond chance to predict CVLT-II from SDMT (61%), albeit statistically significant. In contrast, there was a 77% chance that the model could distinguish between impaired and non-impaired BVMT-R. Several potential explanations are discussed.

Type: Article
Title: The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/13524585221088190
Publisher version: https://doi.org/10.1177/13524585221088190
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Progressive multiple sclerosis, BICAMS, cognition, SDMT, processing speed, memory, INTERNATIONAL COGNITIVE ASSESSMENT, INFORMATION, IMPAIRMENT, VALIDATION, ACQUISITION, PERFORMANCE, FATIGUE
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10150130
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