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Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

Macias, Rocio IR; Cardinale, Vincenzo; Kendall, Timothy J; Avila, Matias A; Guido, Maria; Coulouarn, Cedric; Braconi, Chiara; ... Carpino, Guido; + view all (2022) Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions. Gut 10.1136/gutjnl-2022-327099. (In press). Green open access

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Abstract

Cholangiocarcinoma (CCA) is a malignant tumour arising from the biliary system. In Europe, this tumour frequently presents as a sporadic cancer in patients without defined risk factors and is usually diagnosed at advanced stages with a consequent poor prognosis. Therefore, the identification of biomarkers represents an utmost need for patients with CCA. Numerous studies proposed a wide spectrum of biomarkers at tissue and molecular levels. With the present paper, a multidisciplinary group of experts within the European Network for the Study of Cholangiocarcinoma discusses the clinical role of tissue biomarkers and provides a selection based on their current relevance and potential applications in the framework of CCA. Recent advances are proposed by dividing biomarkers based on their potential role in diagnosis, prognosis and therapy response. Limitations of current biomarkers are also identified, together with specific promising areas (ie, artificial intelligence, patient-derived organoids, targeted therapy) where research should be focused to develop future biomarkers.

Type: Article
Title: Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/gutjnl-2022-327099
Publisher version: http://dx.doi.org/10.1136/gutjnl-2022-327099
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10149969
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