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The moderating role of cognitive reserve markers between childhood cognition and cognitive ageing: evidence from the 1946 UK birth cohort

Almeida-Meza, Pamela; Richards, Marcus; Cadar, Dorina; (2022) The moderating role of cognitive reserve markers between childhood cognition and cognitive ageing: evidence from the 1946 UK birth cohort. Neurology , 99 (12) e1239-e1239. 10.1212/WNL.0000000000200928. Green open access

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Abstract

BACKGGROUND AND OBJECTIVES: As the population ages, differences in cognitive abilities become more evident. We investigated key genetic and life course influences on cognitive state at age 69 years, building on previous work using the longitudinal Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). METHODS: Multivariable regressions investigated the association between 4 factors: (1) childhood cognition at age 8 years; (2) a Cognitive Reserve Index (CRI) composed of 3 markers: (i) educational attainment by age 26 years, (ii) engagement in leisure activities at age 43 years, and (iii) occupation up to age 53 years; (3) reading ability assessed by the National Adult Reading Test (NART) at age 53 years; and (4) APOE genotype in relation to cognitive state measured at age 69 years with Addenbrooke's Cognitive Examination, third edition (ACE-III). We then investigated the modifying role of the CRI, NART, and APOE in the association between childhood cognition and the ACE-III. RESULTS: The analytical sample comprised 1,184 participants. Higher scores in childhood cognition, CRI, and NART were associated with higher scores in the ACE-III. We found that the CRI and NART modified the association between childhood cognition and the ACE-III: for 30 additional points in the CRI or 20 additional points in the NART, the simple slope of childhood cognition decreased by approximately 0.10 points (CRI = 70: marginal effects (MEs) 0.22, 95% CI 0.12–0.32, p < 0.001 vs CRI = 100: MEs 0.12, 95% CI 0.06–0.17, p < 0.001; NART = 15: MEs 0.22, 95% CI 0.09–0.35, p = 0.001, vs NART = 35: MEs 0.11, 95% CI 0.05–0.17, p < 0.001). The association between childhood cognition and the ACE-III was nonsignificant at high levels of the CRI or NART. Furthermore, the e4 allele of the APOE gene was associated with lower scores in the ACE-III (β = −0.71, 95% CI −1.36 to −0.06, p = 0.03) but did not modify the association between childhood cognition and cognitive state in later life. DISCUSSION: The CRI and NART are independent measures of cognitive reserve because both modify the association between childhood cognition and cognitive state.

Type: Article
Title: The moderating role of cognitive reserve markers between childhood cognition and cognitive ageing: evidence from the 1946 UK birth cohort
Open access status: An open access version is available from UCL Discovery
DOI: 10.1212/WNL.0000000000200928
Publisher version: https://doi.org/10.1212/WNL.0000000000200928
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: All Education, Cohort studies, Neuropsychological assessment, Cognitive aging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10149780
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