Haroche, Alexandre;
Giraud, Nolwenn;
Vinckier, Fabien;
Amad, Ali;
Rogers, Jonathan;
Moyal, Mylène;
Canivet, Laetitia;
... Plaze, Marion; + view all
(2022)
Efficacy of Transcranial Direct-Current Stimulation in Catatonia: A Review and Case Series.
Frontiers in Psychiatry
, 13
, Article 876834. 10.3389/fpsyt.2022.876834.
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Abstract
Catatonia is a severe neuropsychiatric syndrome, usually treated by benzodiazepines and electroconvulsive therapy. However, therapeutic alternatives are limited, which is particularly critical in situations of treatment resistance or when electroconvulsive therapy is not available. Transcranial direct-current stimulation (tDCS) is a promising non-invasive neuromodulatory technique that has shown efficacy in other psychiatric conditions. We present the largest case series of tDCS use in catatonia, consisting of eight patients in whom tDCS targeting the left dorsolateral prefrontal cortex and temporoparietal junction was employed. We used a General Linear Mixed Model to isolate the effect of tDCS from other confounding factors such as time (spontaneous evolution) or co-prescriptions. The results indicate that tDCS, in addition to symptomatic pharmacotherapies such as lorazepam, seems to effectively reduce catatonic symptoms. These results corroborate a synthesis of five previous case reports of catatonia treated by tDCS in the literature. However, the specific efficacy of tDCS in catatonia remains to be demonstrated in a randomized controlled trial. The development of therapeutic alternatives in catatonia is of paramount importance.
| Type: | Article |
|---|---|
| Title: | Efficacy of Transcranial Direct-Current Stimulation in Catatonia: A Review and Case Series |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fpsyt.2022.876834 |
| Publisher version: | https://doi.org/10.3389/fpsyt.2022.876834 |
| Language: | English |
| Additional information: | © 2022 Haroche, Giraud, Vinckier, Amad, Rogers, Moyal, Canivet, Berkovitch, Gaillard, Attali and Plaze. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | brain stimulation, case series, catatonia, schizophrenia, transcranial direct-current stimulation |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10149400 |
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