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Building gut from scratch — progress and update of intestinal tissue engineering

Tullie, Lucinda; Jones, Brendan C; De Coppi, Paolo; Li, Vivian SW; (2022) Building gut from scratch — progress and update of intestinal tissue engineering. Nature Reviews Gastroenterology & Hepatology , 19 pp. 417-431. 10.1038/s41575-022-00586-x. Green open access

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Abstract

Short bowel syndrome (SBS), a condition defined by insufficient absorptive intestinal epithelium, is a rare disease, with an estimated prevalence up to 0.4 in 10,000 people. However, it has substantial morbidity and mortality for affected patients. The mainstay of treatment in SBS is supportive, in the form of intravenous parenteral nutrition, with the aim of achieving intestinal autonomy. The lack of a definitive curative therapy has led to attempts to harness innate developmental and regenerative mechanisms to engineer neo-intestine as an alternative approach to addressing this unmet clinical need. Exciting advances have been made in the field of intestinal tissue engineering (ITE) over the past decade, making a review in this field timely. In this Review, we discuss the latest advances in the components required to engineer intestinal grafts and summarize the progress of ITE. We also explore some key factors to consider and challenges to overcome when transitioning tissue-engineered intestine towards clinical translation, and provide the future outlook of ITE in therapeutic applications and beyond.

Type: Article
Title: Building gut from scratch — progress and update of intestinal tissue engineering
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41575-022-00586-x
Publisher version: https://doi.org/10.1038/s41575-022-00586-x
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Gastrointestinal models, Large intestine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10148697
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