Holt, Marie K;
(2022)
The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections.
Journal of Neuroendocrinology
, Article e13132. 10.1111/jne.13132.
(In press).
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Abstract
The body and brain are in constant two-way communication. Driving this communication is a region in the lower brainstem: the dorsal vagal complex. Within the dorsal vagal complex, the caudal nucleus of the solitary tract (cNTS) is a major first stop for incoming information from the body to the brain carried by the vagus nerve. The anatomy of this region makes it ideally positioned to respond to signals of change in both emotional and bodily states. In turn, the cNTS controls the activity of regions throughout the brain that are involved in the control of both behaviour and physiology. This review is intended to help anyone with an interest in the cNTS. First, I provide an overview of the architecture of the cNTS and outline the wide range of neurotransmitters expressed in subsets of neurons in the cNTS. Next, in detail, I discuss the known inputs and outputs of the cNTS and briefly highlight what is known regarding the neurochemical makeup and function of those connections. Then, I discuss one group of cNTS neurons: glucagon-like peptide-1 (GLP-1)-expressing neurons. GLP-1 neurons serve as a good example of a group of cNTS neurons, which receive input from varied sources and have the ability to modulate both behaviour and physiology. Finally, I consider what we might learn about other cNTS neurons from our study of GLP-1 neurons and why it is important to remember that the manipulation of molecularly defined subsets of cNTS neurons is likely to affect physiology and behaviours beyond those monitored in individual experiments.
| Type: | Article |
|---|---|
| Title: | The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jne.13132 |
| Publisher version: | https://doi.org/10.1111/jne.13132 |
| Language: | English |
| Additional information: | © 2022 The Author. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Endocrinology & Metabolism, Neurosciences, Neurosciences & Neurology, afferent, anatomy, efferent, glucagon-like peptide-1, neuropeptides, nucleus of the solitary tract, GLUCAGON-LIKE PEPTIDE-1, DORSAL MOTOR NUCLEUS, PROLACTIN-RELEASING PEPTIDE, C-FOS EXPRESSION, BRAIN-STEM, PARABRACHIAL NUCLEUS, RAT-BRAIN, PARAVENTRICULAR NUCLEUS, EFFERENT PROJECTIONS, FOOD-INTAKE |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10148654 |
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