Chalia, Maria;
Hartmann, Hans;
Pressler, Ronit;
(2022)
Practical Approaches to the Treatment of Neonatal Seizures.
Current Treatment Options in Neurology
, 24
pp. 111-127.
10.1007/s11940-022-00711-w.
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Abstract
Purpose of review: This paper critically reviews the current literature and evidence on diagnosis, classification, clinical approach, and management of neonatal seizures. A stepwise approach for the treatment of neonatal seizures is presented. Recent findings: In a recent randomized controlled trial comparing phenobarbital to levetiracetam as a first-choice anti-seizure medication with primary outcome seizure free for 24 h, the former was found superior (80% vs 28%, p < 0.001). Summary: Neonatal seizures require immediate diagnostic and therapeutic interventions. Phenobarbital is the first-line anti-seizure drug for neonatal seizures, but there is little evidence regarding second-line pharmacotherapy. There is a need for more randomized controlled trials for the use of other existing anti-seizure drugs, yet unlicensed in neonates, and the development of new drugs specifically for neonates.
Type: | Article |
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Title: | Practical Approaches to the Treatment of Neonatal Seizures |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1007/s11940-022-00711-w |
Publisher version: | https://doi.org/10.1007/s11940-022-00711-w |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Seizures, Neonate, Anti-seizure treatment, Electroencephalogram, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, PYRIDOXINE-DEPENDENT EPILEPSY, INDUCED CELL-DEATH, ANTIEPILEPTIC DRUGS, OPEN-LABEL, STATUS EPILEPTICUS, BRAIN-INJURY, LEVETIRACETAM, EEG, HYPOTHERMIA |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10148551 |
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