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Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea

Rajan, L; Radhakrishnan, A; Alagarsamy, KN; Srivastava, A; Dhingra, S; Booker, A; Rolfe, V; ... Mohankumar, SK; + view all (2022) Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea. PharmaNutrition , 20 , Article 100296. 10.1016/j.phanu.2022.100296. Green open access

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Abstract

Cardiovascular disease is a chronic multifactorial health complication that is either directly or indirectly associated with pathophysiological mechanisms, including pro-oxidation, pro-inflammation, vascular and endothelial dysfunction, impaired platelet function, thrombosis, and others. The therapeutic options to circumvent cardiovascular complications include several phytomedicines, including green tea polyphenols. However, while many experimental and clinical studies report distinct mechanisms by which the polyphenols of green tea elicit a beneficial role in cardiometabolic health, the translation and applications of green tea polyphenols in clinics have yet to gain their optimal use on the broader population. This review critically appraises the various reported mechanisms of green tea polyphenols in modulating cardio-metabolic health and associated phyto-genomic challenges. Further, our review highlights the probability of gene polymorphic associated therapeutic variations in individuals using green tea for cardio-metabolic effects and the necessity to personalize green tea for clinical use, thereby improvising the risk-benefit ratio.

Type: Article
Title: Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.phanu.2022.100296
Publisher version: https://doi.org/10.1016/j.phanu.2022.100296
Language: English
Additional information: © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Keywords: Green tea polyphenols, Cardiovascular disease, Inter-individual variability, Genetic polymorphism, Phyto-genomic
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10148433
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