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SARS-CoV-2: from herd immunity to hybrid immunity

Goldblatt, David; (2022) SARS-CoV-2: from herd immunity to hybrid immunity. Nature Reviews Immunology 10.1038/s41577-022-00725-0. (In press).

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Abstract

Herd immunity, where a pathogen can no longer efficiently spread in a population, is achieved when a large proportion of the population becomes immune, making the spread of infection from person to person unlikely and protecting those without immunity. Despite the global spread of SARS-CoV-2, the failure of virus- and vaccine-induced immunity to prevent transmission, combined with the emergence of antigenically distinct variants, has made herd immunity to SARS-CoV-2 unachievable thus far. Where does this leave us?

Type: Article
Title: SARS-CoV-2: from herd immunity to hybrid immunity
Location: England
DOI: 10.1038/s41577-022-00725-0
Publisher version: https://doi.org/10.1038/s41577-022-00725-0
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10148427
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