Paquola, Casey;
Bethlehem, Richard AI;
Seidlitz, Jakob;
Wagstyl, Konrad;
Romero-Garcia, Rafael;
Whitaker, Kirstie J;
Vos de Wael, Reinder;
... Bullmore, Edward T; + view all
(2019)
Shifts in myeloarchitecture characterise adolescent development of cortical gradients.
eLife
, 8
, Article e50482. 10.7554/elife.50482.
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Abstract
We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.
| Type: | Article |
|---|---|
| Title: | Shifts in myeloarchitecture characterise adolescent development of cortical gradients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/elife.50482 |
| Publisher version: | https://doi.org/10.7554/elife.50482 |
| Language: | English |
| Additional information: | Copyright © 2019, Paquola et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10148284 |
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