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Detection of Microcalcifications in Digital Breast Tomosynthesis using Faster R-CNN and 3D Volume Rendering

Mota, Ana M; Clarkson, Matthew J; Almeida, Pedro; Matela, Nuno; (2022) Detection of Microcalcifications in Digital Breast Tomosynthesis using Faster R-CNN and 3D Volume Rendering. In: Gracanin, D and Fred, A and Gamboa, H, (eds.) Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOIMAGING. (pp. pp. 80-89). SciTePress Green open access

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Abstract

Microcalcification clusters (MCs) are one of the most important biomarkers for breast cancer and Digital Breast Tomosynthesis (DBT) has consolidated its role in breast cancer imaging. As there are mixed observations about MCs detection using DBT, it is important to develop tools that improve this task. Furthermore, the visualization mode of MCs is also crucial, as their diagnosis is associated with their 3D morphology. In this work, DBT data from a public database were used to train a faster region-based convolutional neural network (R-CNN) to locate MCs in entire DBT. Additionally, the detected MCs were further analyzed through standard 2D visualization and 3D volume rendering (VR) specifically developed for DBT data. For MCs detection, the sensitivity of our Faster R-CNN was 60% with 4 false positives. These preliminary results are very promising and can be further improved. On the other hand, the 3D VR visualization provided important information, with higher quality and discernment of the detected MCs. The developed pipeline may help radiologists since (1) it indicates specific breast regions with possible lesions that deserve additional attention and (2) as the rendering of the MCs is similar to a segmentation, a detailed complementary analysis of their 3D morphology is possible.

Type: Proceedings paper
Title: Detection of Microcalcifications in Digital Breast Tomosynthesis using Faster R-CNN and 3D Volume Rendering
Event: 15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC) / 9th International Conference on Bioimaging (BIOIMAGING)
Dates: 9th-11th February 2022
Open access status: An open access version is available from UCL Discovery
DOI: 10.5220/0010938800003123
Publisher version: https://doi.org/10.5220/0010938800003123
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Digital Breast Tomosynthesis, Faster R-CNN, Volume Rendering, Microcalcification Clusters
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10147917
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