UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Sexual Dimorphism in Chronic Hepatitis B Virus (HBV) Infection: Evidence to Inform Elimination Efforts [version 2; peer review: 1 approved, 1 approved with reservations]

Brown, Robin; Goulder, Philip; Matthews, Philippa C; (2022) Sexual Dimorphism in Chronic Hepatitis B Virus (HBV) Infection: Evidence to Inform Elimination Efforts [version 2; peer review: 1 approved, 1 approved with reservations]. Wellcome Open Research , 7 , Article 32. 10.12688/wellcomeopenres.17601.2. Green open access

[thumbnail of fe91abc9-5bee-45b8-9736-89e1b2f3bebf_17601_-_philippa_matthews_v2_(1).pdf]
Preview
Text
fe91abc9-5bee-45b8-9736-89e1b2f3bebf_17601_-_philippa_matthews_v2_(1).pdf - Published Version

Download (4MB) | Preview

Abstract

Sexual dimorphism in infectious diseases refers to the different infection susceptibilities and outcomes between males and females, and has been described for many pathogens, including hepatitis B virus (HBV). HBV is a substantial global health problem, with close to 300 million people chronically infected, and accounting for a million deaths each year, with an urgent need for enhanced interventions to support progress towards elimination goals. Sexual dimorphism has a strong influence in HBV infection, with males more likely to be exposed, to develop chronic infection, and to suffer from complications including cirrhosis and hepatocellular carcinoma (HCC) compared to females. Different outcomes are driven by differential immune responses, sexual dimorphism of the liver, and androgen response elements in the HBV genome. The impact of sex may also vary with age, with changes at puberty and influences of menarche, pregnancy and menopause in females. In addition, gender has complex influences on education, beliefs, behaviour and access to / engagement with healthcare services, which may contribute to differences in diagnosis and treatment. Interplay between these complex factors, alongside other attributes of host, virus and the environment, accounts for different outcomes of infection. However, gaps remain in our understanding of sexual dimorphism in HBV, and little effort has previously been made to harness this knowledge for translational gains. In this review, we assimilate human and animal data to consider the mechanism, outcomes and impact of sexual dimorphism, and consider how these insights can be used to inform advances in surveillance, treatment and prevention for HBV infection.

Type: Article
Title: Sexual Dimorphism in Chronic Hepatitis B Virus (HBV) Infection: Evidence to Inform Elimination Efforts [version 2; peer review: 1 approved, 1 approved with reservations]
Open access status: An open access version is available from UCL Discovery
DOI: 10.12688/wellcomeopenres.17601.2
Publisher version: https://doi.org/10.12688/wellcomeopenres.17601.2
Language: English
Additional information: © 2022 Brown R et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: hepatitis, HBV, sex, gender, oestrogen, testosterone, androgen, cancer, hepatocellular carcinoma, gender, stigma, epidemiology, outcome, treatment, dimorphism
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10147761
Downloads since deposit
5Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item