Pich, Oriol;
Bailey, Chris;
Watkins, Thomas BK;
Zaccaria, Simone;
Jamal-Hanjani, Mariam;
Swanton, Charles;
(2022)
The translational challenges of precision oncology.
Cancer Cell
, 40
(5)
pp. 458-478.
10.1016/j.ccell.2022.04.002.
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Abstract
The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease. Technological advances in genomics have facilitated large sequencing efforts and discoveries that have further supported this notion. In this review, we reflect on the impact of these discoveries on our understanding of several concepts: cancer initiation, cancer prevention, early detection, adjuvant therapy and minimal residual disease monitoring, cancer drug resistance, and cancer evolution in metastasis. We discuss key areas of focus for improving cancer outcomes, from biological insights to clinical application, and suggest where the development of these technologies will lead us. Finally, we discuss practical challenges to the wider adoption of molecular profiling in the clinic and the need for robust translational infrastructure.
| Type: | Article |
|---|---|
| Title: | The translational challenges of precision oncology |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ccell.2022.04.002 |
| Publisher version: | https://doi.org/10.1016/j.ccell.2022.04.002 |
| Language: | English |
| Additional information: | This research was funded in whole, or in part, by the Wellcome Trust (FC001169). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
| Keywords: | cancer evolution, cancer genomics, drug resistance |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10147705 |
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