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The translational challenges of precision oncology

Pich, Oriol; Bailey, Chris; Watkins, Thomas BK; Zaccaria, Simone; Jamal-Hanjani, Mariam; Swanton, Charles; (2022) The translational challenges of precision oncology. Cancer Cell , 40 (5) pp. 458-478. 10.1016/j.ccell.2022.04.002. Green open access

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Abstract

The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease. Technological advances in genomics have facilitated large sequencing efforts and discoveries that have further supported this notion. In this review, we reflect on the impact of these discoveries on our understanding of several concepts: cancer initiation, cancer prevention, early detection, adjuvant therapy and minimal residual disease monitoring, cancer drug resistance, and cancer evolution in metastasis. We discuss key areas of focus for improving cancer outcomes, from biological insights to clinical application, and suggest where the development of these technologies will lead us. Finally, we discuss practical challenges to the wider adoption of molecular profiling in the clinic and the need for robust translational infrastructure.

Type: Article
Title: The translational challenges of precision oncology
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ccell.2022.04.002
Publisher version: https://doi.org/10.1016/j.ccell.2022.04.002
Language: English
Additional information: This research was funded in whole, or in part, by the Wellcome Trust (FC001169). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Keywords: cancer evolution, cancer genomics, drug resistance
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10147705
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