Atsamnia, Djamel;
Hanini, Salah;
Oukrif, Dahmane;
Benachour, Karine;
Benkortbi, Othmane;
Hamadache, Mabrouk;
(2022)
Comparative Therapeutic Properties of Garlic Extract and Metformin on Hyperglycaemia, Hypercholesterolaemia, and Hypertriglyceridaemia in Alloxan-induced Type1-like Diabetic Rats.
Kemija u Industriji
, 71
(3-4)
pp. 141-149.
10.15255/kui.2021.035.
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Abstract
The current pilot study was conducted to compare the triple effect of garlic extract and metformin on hyperglycaemia, hypercholesterolaemia, and hypertriglyceridaemia in alloxan-induced type 1-like diabetic rats. Wistar rats were randomly divided into four groups. Control group included normal rats. The second group included alloxan-induced type 1-like diabetic rats, receiving no treatment. The other two groups of diabetic rats were orally treated with 0.75 g of garlic extract per kg of body weight and 0.05 of metformin g per kg of body weight respectively for four weeks. The pharmacological impact of garlic compounds on serum glucose and lipids as opposed to the glucose-lowering and lipid-lowering was highlighted in these experiments. These results revealed that garlic extract has a triple action on hyperglycaemia, hypertriglyceridemia, and hypercholesterolemia. Its effect on hyperglycaemia is long lasting, and more pronounced compared to the metformin. Interestingly, it had a regulatory effect on glycaemia as highlighted in the control group.
| Type: | Article |
|---|---|
| Title: | Comparative Therapeutic Properties of Garlic Extract and Metformin on Hyperglycaemia, Hypercholesterolaemia, and Hypertriglyceridaemia in Alloxan-induced Type1-like Diabetic Rats |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15255/kui.2021.035 |
| Publisher version: | https://doi.org/10.15255/KUI.2021.035 |
| Language: | English |
| Additional information: | © The Authors 2022. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | alloxan, diabetes, garlic extract, glycaemia, metformin |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10147494 |
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