Brand, DH;
Kirby, AM;
Yarnold, JR;
Somaiah, N;
(2022)
How Low Can You Go? The Radiobiology of Hypofractionation.
Clinical Oncology
, 34
(5)
pp. 280-287.
10.1016/j.clon.2022.02.009.
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Abstract
Hypofractionated radical radiotherapy is now an accepted standard of care for tumour sites such as prostate and breast cancer. Much research effort is being directed towards more profoundly hypofractionated (ultrahypofractionated) schedules, with some reaching UK standard of care (e.g. adjuvant breast). Hypofractionation exerts varying influences on each of the major clinical end points of radiotherapy studies: acute toxicity, late toxicity and local control. This review will discuss these effects from the viewpoint of the traditional 5 Rs of radiobiology, before considering non-canonical radiobiological effects that may be relevant to ultrahypofractionated radiotherapy. The principles outlined here may assist the reader in their interpretation of the wealth of clinical data presented in the tumour site-specific articles in this special issue.
| Type: | Article |
|---|---|
| Title: | How Low Can You Go? The Radiobiology of Hypofractionation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clon.2022.02.009 |
| Publisher version: | https://doi.org/10.1016/j.clon.2022.02.009 |
| Language: | English |
| Additional information: | © 2022 The Authors. Published by Elsevier Ltd on behalf of The Royal College of Radiologists. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Hypofractionation, radiobiology, Breast, Breast Neoplasms, Humans, Male, Prostatic Neoplasms, Radiation Dose Hypofractionation, Radiobiology, Treatment Outcome |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10147471 |
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