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Nano toolbox in immune modulation and nanovaccines.

Azharuddin, Mohammad; Zhu, Geyunjian Harry; Sengupta, Anirban; Hinkula, Jorma; Slater, Nigel KH; Patra, Hirak K; (2022) Nano toolbox in immune modulation and nanovaccines. Trends in Biotechnology 10.1016/j.tibtech.2022.03.011. (In press). Green open access

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Abstract

Despite the great success of vaccines over two centuries, the conventional strategy is based on attenuated/altered microorganisms. However, this is not effective for all microbes and often fails to elicit a protective immune response, and sometimes poses unexpected safety risks. The expanding nano toolbox may overcome some of the roadblocks in vaccine development given the plethora of unique nanoparticle (NP)-based platforms that can successfully induce specific immune responses leading to exciting and novel solutions. Nanovaccines necessitate a thorough understanding of the immunostimulatory effect of these nanotools. We present a comprehensive description of strategies in which nanotools have been used to elicit an immune response and provide a perspective on how nanotechnology can lead to future personalized nanovaccines.

Type: Article
Title: Nano toolbox in immune modulation and nanovaccines.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibtech.2022.03.011
Publisher version: https://doi.org/10.1016/j.tibtech.2022.03.011
Language: English
Additional information: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: immune modulation, immune response, nano toolbox, nanovaccine, vaccine
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10147408
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