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The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study

Bloomfield, Michael AP; Yamamori, Yumeya; Hindocha, Chandni; Jones, Augustus PM; Yim, Jocelyn LL; Walker, Hannah R; Statton, Ben; ... Freeman, Tom P; + view all (2022) The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study. Psychopharmacology 10.1007/s00213-022-06070-3. (In press). Green open access

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Abstract

Rationale: There is growing interest in the therapeutic potential of cannabidiol (CBD) across a range of psychiatric disorders. CBD has been found to reduce anxiety during experimentally induced stress in anxious individuals and healthy controls. However, the mechanisms underlying the putative anxiolytic effects of CBD are unknown. // Objectives: We sought to investigate the behavioural and neural effects of a single dose of CBD vs. placebo on a range of emotion-related measures to test cognitive-mechanistic models of its effects on anxiety. // Methods: We conducted a randomised, double-blind, placebo-controlled, crossover, acute oral challenge of 600 mg of CBD in 24 healthy participants on emotional processing, with neuroimaging (viewing emotional faces during functional magnetic resonance imaging) and cognitive (emotional appraisal) measures as well as subjective response to experimentally induced anxiety. // Results: CBD did not produce effects on brain responses to emotional faces and cognitive measures of emotional processing, or modulate experimentally induced anxiety, relative to placebo. // Conclusions: Given the rising popularity of CBD for its putative medical benefits, these findings question whether further research is warranted to investigate the clinical potential of CBD for the treatment of anxiety disorders.

Type: Article
Title: The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00213-022-06070-3
Publisher version: https://doi.org/10.1007/s00213-022-06070-3
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
Keywords: Anxiety, Cannabidiol, Cannabinoids, Emotional processing, Neuroimaging, fMRI
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10147396
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