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Hypervitaminosis D and nephrocalcinosis: too much of a good thing?

Wan, Mandy; Patel, Jignesh; Rait, Greta; Shroff, Rukshana; (2022) Hypervitaminosis D and nephrocalcinosis: too much of a good thing? Pediatric Nephrology , 37 pp. 2225-2229. 10.1007/s00467-022-05513-5. Green open access

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Abstract

The worldwide interest in vitamin D appears insatiable and shows no sign of abating. Literature on vitamin D spans a wide range of clinical specialties, including endocrinology, immunology, and nephrology, among many others. In almost all fields, the same debate continues with both proponents and opponents of vitamin D supplementation, yet questions of “how much” and “for how long” remain subjects of considerable discussion but with no clear consensus among clinicians or researchers. Despite little compelling evidence of benefit on almost all of the health outcomes investigated to date [1, 2], the last two decades have witnessed a significant increase in vitamin D consumption [3,4,5,6]. This may reflect in part the increased testing for vitamin D deficiency in response to widespread public health initiatives [5, 7, 8]. On the other hand, evidence of indiscriminate use of vitamin D supplements may suggest an emerging “more is better” attitude which deserves our attention [9,10,11].

Type: Article
Title: Hypervitaminosis D and nephrocalcinosis: too much of a good thing?
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00467-022-05513-5
Publisher version: https://doi.org/10.1007/s00467-022-05513-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
URI: https://discovery.ucl.ac.uk/id/eprint/10147204
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