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Translation Reprogramming as a Novel Therapeutic Target in MAFLD

Metwally, Mayada; Berg, Thomas; Tsochatzis, Emmanuel A; Eslam, Mohammed; (2022) Translation Reprogramming as a Novel Therapeutic Target in MAFLD. Advanced Biology , 6 (5) , Article 2101298. 10.1002/adbi.202101298. Green open access

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Abstract

Approved pharmacotherapies for metabolic-dysfunction-associated fatty liver disease (MAFLD) are lacking. Novel approaches and therapeutic targets that are likely to translate to clinical benefit are required. Targeting components of the translation machinery hold promise as a novel therapeutic approach that can overcome the well-known disease heterogeneity, as dysregulation of mRNA translation is a common feature independent of the MAFLD drivers. In this perspective, recent advances in understanding the role of mRNA translation in MAFLD are discussed, with a particular focus on the potential implications and challenges to “translate” these findings to the clinic, and an overview of similar recent efforts in other diseases is provided.

Type: Article
Title: Translation Reprogramming as a Novel Therapeutic Target in MAFLD
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/adbi.202101298
Publisher version: https://doi.org/10.1002/adbi.202101298
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: metabolic-dysfunction-associated fatty liver disease, mRNA translation, therapeutic
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10147184
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