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Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?

Pley, Caitlin; Lourenço, José; McNaughton, Anna L; Matthews, Philippa C; (2022) Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? Journal of Virology 10.1128/jvi.00051-22. (In press). Green open access

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Abstract

Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes.

Type: Article
Title: Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/jvi.00051-22
Publisher version: https://doi.org/10.1128/jvi.00051-22
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10147096
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