UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension

Gollifer, Ruaridh M; Taylor, Stuart A; Menys, Alex; Zarate‐Lopez, Natalia; Chatoor, Dave; Emmanuel, Anton; Atkinson, David; (2022) Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension. Neurogastroenterology and Motility 10.1111/nmo.14381. (In press). Green open access

[thumbnail of Neurogastroenterology Motil - 2022 - Gollifer - Magnetic resonance imaging assessed enteric motility and luminal content.pdf]
Preview
PDF
Neurogastroenterology Motil - 2022 - Gollifer - Magnetic resonance imaging assessed enteric motility and luminal content.pdf - Published Version

Download (1MB) | Preview

Abstract

Background: Gastrointestinal symptoms in functional gut disorders occur without any discernible structural gut abnormality. Preliminary observations on enteric MRI suggest possible abnormal content and motility of the terminal ileum (TI) in constipation-predominant IBS (IBS-C) with severe bloating, and in functional bloating and distension (FABD) patients. We investigated whether MRI can quantify differences in small bowel (SB) content and motility between patients and healthy controls (HCs). Methods: 11 IBS-C (mean age 40 [21–52] years; 10 women) and 7 FABD (36 [21–56]; all women) patients with bloating and 20 HCs (28 [22–48]; 6 women) underwent enteric MRI, including dynamic motility and anatomical sequences. Three texture analysis (TA) parameters assessed the homogeneity of the luminal content, with ratios calculated between the TI and (1) the SB and (2) the ascending colon. Four TI motility metrics were derived. Ascending colon diameter (ACD) was measured. A comparison between HCs and patients was performed independently for: (1) three TA parameters, (2) four TI motility metrics, and (3) ACD. Key Results: Compared with HCs, patients had TI:colon ratios higher for TA contrast (p < 0.001), decreased TI motility (lower mean motility [p = 0.04], spatial motility variation [p = 0.03], and area of motile TI [p = 0.03]), and increased ACD (p = 0.001). Conclusions and Inferences: IBS-C and FABD patients show reduced TI motility and differences in luminal content compared with HCs. This potentially indicates reflux of colonic contents or delayed clearance of the TI, which alongside increased ACD may contribute to symptoms of constipation and bloating.

Type: Article
Title: Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nmo.14381
Publisher version: https://doi.org/10.1111/nmo.14381
Language: English
Additional information: © 2022 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10147070
Downloads since deposit
47Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item