Jing, Chunlan;
Chen, Shenmao;
Bhatia, Sehajdev Singh;
Li, Bowen;
Liang, Hongze;
Liu, Chaozong;
Liang, Zhenjiang;
... Zhao, Lingling; + view all
(2022)
Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment.
Polymer Testing
, 110
, Article 107584. 10.1016/j.polymertesting.2022.107584.
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Abstract
Bone-targeted polymeric nanoparticles for alendronate delivery based on Poly (lactic-co-glycolic acid) conjugated chitosan (CS-PLGA) and alendronate conjugated PLGA (Alen-PLGA) are fabricated and their superior performances are evaluated. The nanoparticles exhibited sustained Alen release without obvious burst release and good cytocompatibility against MC3T3 cells. Alen-modified nanoparticles demonstrated a high affinity to hydroxyapatite, which is the main mineral component of bone, indicating their feasibility for bone-targeted delivery. In addition, unlike nanoparticles without Alen, Alen-modified nanoparticles were preferentially taken up by MC3T3 cells, compared to HDF cells, revealing their specific uptake for osteoblast-like cells. Thus, the Alen-modified nanoparticles can potentially be developed as bone-targeted carriers for osteoporosis treatment.
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