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Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment

Jing, Chunlan; Chen, Shenmao; Bhatia, Sehajdev Singh; Li, Bowen; Liang, Hongze; Liu, Chaozong; Liang, Zhenjiang; ... Zhao, Lingling; + view all (2022) Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment. Polymer Testing , 110 , Article 107584. 10.1016/j.polymertesting.2022.107584. Green open access

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Abstract

Bone-targeted polymeric nanoparticles for alendronate delivery based on Poly (lactic-co-glycolic acid) conjugated chitosan (CS-PLGA) and alendronate conjugated PLGA (Alen-PLGA) are fabricated and their superior performances are evaluated. The nanoparticles exhibited sustained Alen release without obvious burst release and good cytocompatibility against MC3T3 cells. Alen-modified nanoparticles demonstrated a high affinity to hydroxyapatite, which is the main mineral component of bone, indicating their feasibility for bone-targeted delivery. In addition, unlike nanoparticles without Alen, Alen-modified nanoparticles were preferentially taken up by MC3T3 cells, compared to HDF cells, revealing their specific uptake for osteoblast-like cells. Thus, the Alen-modified nanoparticles can potentially be developed as bone-targeted carriers for osteoporosis treatment.

Type: Article
Title: Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.polymertesting.2022.107584
Publisher version: https://doi.org/10.1016/j.polymertesting.2022.1075...
Language: English
Additional information: © 2022 Published by Elsevier Ltd under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Osteoporosis, Nanoparticles, Bone-targeted, Alendronate
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10146874
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