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Life course trajectories of affective symptoms and their early life predictors

Richards, Marcus; Thompson, Ellen J; Ploubidis, George B; Gaysina, Darya; (2022) Life course trajectories of affective symptoms and their early life predictors. Longitudinal and Life Course Studies (In press).

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Abstract

Background: Life course trajectories of affective symptoms (i.e., depression and anxiety) are heterogenous. However, few studies have investigated the role of early life risk factors in the development of these trajectories. The present study aimed to: 1) derive latent trajectories of affective symptoms over a period of more than 50 years (from age 13 through age 69), and 2) examine early life risk factors for associations with specific life course trajectories of affective symptoms. Method: Participants are from the MRC National Survey of Health and Development (NSHD) (n = 5362). Affective symptoms were measured prospectively at ages 13, 15, 36, 43, 53, 60-64 and 69. A latent variable modelling framework was implemented to model longitudinal profiles of affective symptoms. Twenty-four prospectively measured early life predictors were tested for associations with different symptom profiles using multinomial logistic regression. Results: Four life course profiles of affective symptoms were identified: 1) absence of symptoms (66.6% of the sample); 2) adolescent symptoms with good adult outcome (15.2%); 3) adult symptoms only (with no symptoms in adolescence and late life) (12.9%); 4) symptoms in adolescence and mid adulthood (5.2%). Of the twenty-four early life predictors observed, only four were associated with life course trajectories, with small effect sizes observed. Conclusions: People differ in their life course trajectories of anxiety and depression symptoms and that these differences are not largely influenced by early life factors tested in this study.

Type: Article
Title: Life course trajectories of affective symptoms and their early life predictors
Publisher version: https://bristoluniversitypress.co.uk/journals/long...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10146859
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