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Surface enhanced deep Raman detection of cancer tumour through 71 mm of heterogeneous tissue

Dey, P; Vaideanu, A; Mosca, S; Salimi, M; Gardner, B; Palombo, F; Uchegbu, I; ... Stone, N; + view all (2022) Surface enhanced deep Raman detection of cancer tumour through 71 mm of heterogeneous tissue. Nanotheranostics , 6 (3) pp. 337-349. 10.7150/ntno.71510. Green open access

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Abstract

Detection of solid tumours through tissue− from depths relevant to humans− has been a significant challenge for biomedical Raman spectroscopy. The combined use of surface enhanced Raman scattering (SERS) imaging agents with deep Raman spectroscopy (DRS), i.e., surface enhanced deep Raman spectroscopy (SEDRS), offer prospects for overcoming such obstacles. In this study, we investigated the maximum detection depth through which the retrieval of SERS signal of a passively targeted biphenyl-4-thiol tagged gold nanoparticle (NP) imaging agent, injected subcutaneously into a mouse bearing breast cancer tumour, was possible. A compact 830 nm set-up with a hand-held probe and the flexibility of switching between offset, transmission and conventional Raman modalities was developed for this study. In vivo injection of the above SERS NP primary dose allowed surface tumour detection, whereas additional post mortem NP booster dose was required for detection of deeply seated tumours through heterogeneous animal tissue (comprising of proteins, fat, bone, organs, blood, and skin). The highest detection depth of 71 mm was probed using transmission, translating into a ∼40% increase in detection depth compared to earlier reports. Such improvements in detection depth along with the inherent Raman chemical sensitivity brings SEDRS one step closer to future clinical cancer imaging technology.

Type: Article
Title: Surface enhanced deep Raman detection of cancer tumour through 71 mm of heterogeneous tissue
Open access status: An open access version is available from UCL Discovery
DOI: 10.7150/ntno.71510
Publisher version: https://doi.org/10.7150/ntno.71510
Language: English
Additional information: ©2022 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: Plasmonic gold nanoparticles, SERS, SORS, TRS, SESORS, SEDRS mouse breast cancer, cancer tumour detection
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10146800
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