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Relevance of genomic diversity of Mycobacterium tuberculosis complex in Africa

Osei-Wusu, Stephen; Otchere, Isaac Darko; Asare, Prince; Ntoumi, Francine; Zumla, Alimuddin; Asante-Poku, Adwoa; Yeboah-Manu, Dorothy; (2022) Relevance of genomic diversity of Mycobacterium tuberculosis complex in Africa. International Journal of Infectious Diseases 10.1016/j.ijid.2022.03.016. (In press). Green open access

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Abstract

BACKGROUND: The diversity in the lineages of Mycobacterium tuberculosis complex (MTBC) was initially considered insignificant. However, comparative genomics analysis of MTBC have found genomic variation among the genotypes with potential phenotypic implications. OBJECTIVE: Therefore, this viewpoint seeks to discuss the impact of the identified genotypic diversity on the physiology of MTBC and the potential implications on TB control. RESULTS: Studies conducted in West Africa and other parts of Africa have unravelled the implications of the genomic diversity on phenotypes such as disease outcome, transmission dynamics and host immune response. The understanding of the phenotypic diversity among the different lineages of MTBC may be an important key to the fight against TB. CONCLUSION: The relevance of these differences has been observed in the design of new control tools such as diagnostics and anti-TB drugs/vaccines. This only points to the fact that the diversity in MTBC cannot be ignored in future studies especially clinical trials for new vaccines and new anti-TB drugs.

Type: Article
Title: Relevance of genomic diversity of Mycobacterium tuberculosis complex in Africa
Location: Canada
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijid.2022.03.016
Publisher version: https://doi.org/10.1016/j.ijid.2022.03.016
Language: English
Additional information: © 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Mycobacterium tuberculosis; Mycobacterium africanum; Africa; West Africa; Genomic Diversity
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10146788
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