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PARPs: All for One and One for All? Enhancing Diversity in Clinical Trials

Nicum, Shibani; Blagden, Sarah P; (2022) PARPs: All for One and One for All? Enhancing Diversity in Clinical Trials. Clinical Cancer Research 10.1158/1078-0432.CCR-22-0442. (In press).

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Abstract

PARP inhibitors have revolutionized the management of ovarian cancer and are being licenced for other cancer indications. The clinical trials prompting licencing decisions in ovarian cancer were dominated by white participants or participant ethnicity was not documented. To compensate for this, replicative studies like L-MOCA can be run in specific ethnic groups. In future, strategies such as mandatory collection and publication of race and ethnicity data are essential alongside concerted efforts to widen the inclusivity of trial recruitment.

Type: Article
Title: PARPs: All for One and One for All? Enhancing Diversity in Clinical Trials
Location: United States
DOI: 10.1158/1078-0432.CCR-22-0442
Publisher version: https://doi.org/10.1158/1078-0432.CCR-22-0442
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10146748
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